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Articles

P Reddanna

   Prof. Pallu Reddanna, Ph. D. (S. V. University, Tirupati)
   Department of Animal Sciences
   School of Life Sciences
   University of Hyderabad
   Prof. C.R.Rao Road, Gachibowli
   Hyderabad, 500046, India
   Tel: +91 40 23134542
   Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. (or) This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

Research Interests:

Inflammation is a necessary response of the host to invading pathogens to mediate removal of microbes or irritants and restore the tissue to its normal function. However, sometimes this process goes awry and the tissue fails to undergo resolution of the inflammation and results in the onset of chronic inflammatory diseases such as allergy, asthma, autoimmune diseases, rheumatoid arthritis, prostatitis, nephritis, mastitis and even in cancer.

Eicosanoids, the oxygenated metabolites of arachidonic acid formed via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways are known to be important regulators of both the onset and resolution of inflammatory processes. The main focus of our group is to understand how these eicosanoids regulate both the development and resolution of inflammation and design safer and more effective anti-inflammatory drugs. 

Administrative Positions: 

  • Dean, School of Life Sciences, University of Hyderabad (Jan 2015 onwards)
  • OSD/Founding Director, National Institute of Animal Biotechnology (NIAB), Department of Biotechnology (DBT), Govt. of India (2010-2014).
  • Coordinator, Centre for Biotechnology, University of Hyderabad (2006-2008)
  • Head, Department of Animal Sciences, University of Hyderabad (1999-2002)

Awards/Honours/Fellowships:

  • President, Federation of Asian Biotech Associations (FABA) India chapter- 2014 onwards
  • Vice President, FABA- 2013 onwards
  • ‘Applied Zoologists Research Association (AZRA) Honorary Fellow’, Applied Zoologists Research Association (AZRA) - 2009
  • ‘Outstanding Scientist Award for Benefit of Industry’ from FAPCCI- 2007
  • ‘Best Research Project Award’  from Royan International Foundation, Tehran, Iran-2007
  • ‘Outstanding Contribution Award (Pharma)’ from Chemtech Foundation, 2005
  • ‘The Rockefeller Foundation Biotechnology Career Award’- 1993-1996.
  • ‘Overseas Post-Doctoral Fellowship’ from Ministry of Education & Culture, Govt. of India-1984-87

Significant Publications (Out of 180):

  1. Horn T, Adel S, Schumann R, Sur S, Kakularam KR, Polamarasetty A, Reddanna P, Kuhn H, Heydeck D. (2015) Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling. Prog Lipid Res.  2015; 57:13-39.
  2. Reddy MR, Reddy CR, Rathore RS, Erion MD, Aparoy P, Reddy RN, Reddanna P. (2014)  Free energy calculations to estimate ligand-binding affinities in structure-based drug design. Curr Pharm Des. 20(20):3323-37.
  3. Aparoy P, Reddy KK, Reddanna P (2012). Structure and ligand based drug design strategies in the development of novel 5- LOX inhibitors. Curr Med Chem. 19(22):3763-78.
  4. Reddy NP, Chandramohan Reddy T, Aparoy P, Achari C, Sridhar PR, . (2012) Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors. . 47(1):351-9.Reddanna PEur J Med Chem
  5. Nishanth RP, Jyotsna RG, Schlager JJ, Hussain SM, Reddanna P. (2011) Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: role of ROS-NFκB signaling pathway. Nanotoxicology. 5(4):502-16.
  6. Achari C, Reddy GV, Reddy TC, Reddanna P. (2011) Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1. Med Chem. 7(5):432-42.
  7. Agarwal S, Achari C, Praveen D, Roy KR, Reddy GV, Reddanna P. Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways. Exp Dermatol. 2009 Nov;18(11):939-46.
  8. Mahipal SV, Subhashini J, Reddy MC, Reddy MM, Anilkumar K, Roy KR, Reddy GV, Reddanna P. Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. Biochem Pharmacol. 2007 Jul 15;74(2):202-14. Epub 2007 Apr 7.
  9. Sathyasaikumar KV, Swapna I, Reddy PV, Murthy ChR, Roy KR, Dutta Gupta A, Senthilkumaran B,Reddanna P. Co-administration of C-Phycocyanin ameliorates thioacetamide-induced hepatic encephalopathy in Wistar rats. J Neurol Sci. 2007 Jan 15;252(1):67-75.
  10. Meruvu S, Walther M, Ivanov I, Hammarström S, Fürstenberger G, Krieg P, Reddanna P, Kuhn H.Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. J Biol Chem. 2005 Nov 4;280(44):36633-41. Epub 2005 Aug 29.

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  https://scholar.google.co.in/citations?user=xCp2iFoAAAAJ&hl=en